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TeachMeFinance.com - explain Tetraploid complementation assay Tetraploid complementation assay The term 'Tetraploid complementation assay' as it applies to the area of stem cell research can be defined as 'An assay that can be used to test a stem cell's potency. Scientists studying mouse chimeras (mixing cells of two different animals) noted that fusing two 8-cell embryos produces cells with 4 sets of chromosomes (tetraploid cells) that are biased toward developing into extra-embryonic tissues such as the placenta. The tetraploid cells do not generate the embryo itself; the embryo proper develops from injected diploid stem cells. This tendency has been exploited to test the potency of a stem cell. Scientists begin with a tetraploid embryo. Next, they inject the stem cells to be tested. If the injected cells are pluripotent, then an embryo develops. If no embryo develops, or if the resultant embryo cannot survive until birth, the scientists conclude that the cells were not truly pluripotent'. Previous 5 Terms: Test pit Test well contribution testaceous testudinal tetanigenous Next 5 Terms: teuthology tex Texas Hooker textology textorial About the author Mark McCracken Author: Mark McCracken is a corporate trainer and author living in Higashi Osaka, Japan. He is the author of thousands of online articles as well as the Business English textbook, "25 Business Skills in English". Copyright © 2005-2011 by Mark McCracken, All Rights Reserved. TeachMeFinance.com is an informational website, and should not be used as a substitute for professional medical, legal or financial advice. Information presented at TeachMeFinance.com is provided on an "AS-IS" basis. Please read the disclaimer for details.